宫性HPV阳性增加了口腔HPV感染的风险:通过元分析进行系统性审查
A E Mózes1,2, F H Olasz1,2, P Martineková1
1Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Journal of dental research
|June 24, 2025
概括
宫人类乳头瘤病毒 (HPV) 感染的女性患口腔HPV的风险更高. 在这群人群中,建议对口腔HPV进行查,特别是在细胞质阳性的人群中.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的性传播感染,与各种癌症有关.
- 口腔癌的发病率正在上升,但口腔HPV查缺乏FDA的建议,因为流行率低,没有通用工具.
- 了解宫和口腔HPV之间的联系对于识别风险人群至关重要.
研究的目的:
- 评估女性宫和口腔HPV感染之间的关联.
- 为了确定口服HPV携带风险较高的妇女的特定子组.
- 为潜在的口腔HPV查策略提供信息.
主要方法:
- 在PubMed,EMBASE和CENTRAL数据库中进行了系统的搜索.
- 包括41项分析性观察性研究,研究了宫HPV阳性或无宫HPV阳性女性的口腔HPV状况.
- 随机效应模型被用于对效应大小 (比例,赔率比率) 和子组分析的元分析.
主要成果:
- 与没有宫HPV的女性相比,宫HPV阳性女性的口腔HPV几率比率为2.22.
- 口服HPV的患病率在宫HPV阳性女性 (13%) 与HPV阴性女性 (4%) 之间显着更高.
- 口服HPV患病率最高的是宫HPV阳性女性的阳性细胞学 (17%).
结论:
- 宫性HPV阳性与口腔HPV感染的风险增加有关.
- 患有宫性HPV的女性,特别是细胞质阳性女性,是口腔HPV的关键风险组.
- 在患有宫性HPV的妇女中,考虑口服HPV查是有必要的,因为八分之一的女性携带口服HPV.
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