在国家预防计划中,与乙型肝炎母婴传播相关的因素
Moran Ki1, Byung-Woo Kim1, Dahye Baik1
1Department of Public Health & AI, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.
Clinical and molecular hepatology
|June 24, 2025
概括
韩国B型肝炎母婴传播 (MTCT) 率随着抗病毒使用,母乳养和剖腹产显著下降. 这些干预措施是防止全球慢性乙型肝炎感染的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 母婴传播 (MTCT) 是慢性HBV感染的主要原因.
- 预防围产期HBV感染对全球卫生和HBV消除工作至关重要.
研究的目的:
- 评估韩国HBV MTCT率的长期趋势.
- 在国家预防计划中确定与减少MTCT相关的因素.
主要方法:
- 基于人口的队列研究,使用来自韩国周产期乙型肝炎预防计划 (PHBPP) 和国家医疗保险服务的链接数据.
- 分析包括2002年至2021年的HBsAg阳性母婴对,以及接种疫苗后的血清学结果.
主要成果:
- 预防后的整体MTCT率在154,478个母婴对中为2.3%.
- 抗病毒使用显著降低了MTCT (0.9%对2.4%),特别是在HBeAg阳性母亲 (1.0%对5.9%).
- 剖腹产 (1.9%对2.6%) 和母乳养 (1.8%对2.8%) 与较低的MTCT率有关. 年度MTCT费率从3.6% (2002-2005) 降至1.3% (2018-2021年).
结论:
- 韩国周产期乙型肝炎预防计划通过抗病毒药物,母乳养和剖腹产有效降低了MTCT的发生率.
- 这些发现支持将这些策略纳入全球HBV MTCT预防工作.
- 优化的抗病毒时间和持续时间进一步增强了MTCT的减少.
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