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中性粒细胞衰老的增加与系统性红血狼的免疫抑制活性受损有关

Lei Han¹, Fengling Huang², Qingchen Zhu²

¹Department of Rheumatology, Shanghai East Hospital, Tongji University, School of Medicine, Shanghai 200120, China.

Acta biochimica et biophysica Sinica

|June 24, 2025

概括

中性粒细胞衰老,以CXCR4hiCD62Llo细胞为特征,在全身性红斑狼 (SLE) 患者中升高. 这些细胞与疾病活性相关,并且免疫抑制功能受损,为狼提供了新的治疗点.

科学领域:

免疫学免疫学免疫学
自免疫性疾病自免疫性疾病
细胞衰老细胞衰老

背景情况:

系统性红斑狼 (SLE) 的发病因子传统上与适应性免疫有关.
新兴研究强调了中性粒细胞在SLE免疫失调和器官损伤中的关键作用.
中性粒细胞衰老在SLE的具体参与仍未得到充分研究.

研究的目的:

为了研究中性粒细胞衰老的动态在SLE.
探索衰老类中性粒细胞与SLE疾病活动之间的关系.
了解这些中性粒细胞对其他免疫细胞的功能影响.

主要方法:

流细胞计用于识别和量化SLE患者和健康捐赠者的衰老类中性粒细胞 (CXCR4hiCD62Llo).
分析了老化样中性粒细胞数量与临床参数 (疾病活性,自身抗体) 之间的相关性.
功能性测试评估了SLE衍生的衰老类中性粒细胞抑制NK细胞和CD4+T细胞活性的能力.

主要成果:

与健康个体相比,SLE患者的CXCR4hiCD62Llo衰老类中性粒细胞比例显著更高.
衰老类中性粒细胞的数量与SLE疾病活性和自身抗体水平有积极的相关性.
来自SLE患者的衰老类中性粒细胞显示其抑制NK细胞和CD4+T细胞的炎症反应的能力有所降低,可能通过ROS生产.

结论:

升高的衰老类中性粒细胞 (CXCR4hiCD62Llo) 是SLE患者的一个明显特征.
这些中性粒细胞作为SLE疾病活动的潜在生物标志物.
衰老类中性粒细胞的免疫抑制功能受损,为SLE病理生理学和潜在的治疗策略提供了新的见解.

关键词:

抑制能力的抑制能力.中性粒细胞中性粒细胞.有活性氧物种的反应性氧物种.衰老是一种老化.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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