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Updated: Sep 18, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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在寻找一种可光切换的药物用于血清素受体:一个分子动力学模拟研究研究

Arshjot S Dhaliwal1, Arunima Verma1, Padmabati Mondal1

  • 1Department of Chemistry, Indian Institute of Science Education and Research Srinivasapuram, Yerpedu Mandal Tirupati Dist. Andhra Pradesh 517619 India padmabati.mondal@iisertirupati.ac.in +91 8772500926.

RSC advances
|June 24, 2025
PubMed
概括

研究人员使用亚博烯开发了可光切换的血清药物. 跨同位素 (TAS) 与 cis 同位素 (CAS) 不一样,有效地与血清素受体结合,为向心理健康治疗提供了潜在的潜力.

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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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