在2型糖尿病中,血清25-基维生素D水平与外周神经病变之间的相关性
Senzhen Chen1, Jinfeng Chen1, Shujing Zheng2
1Zhangzhou Affiliated Hospital of Fujian Medical University, The Second Department of Endocrinology and Metabolism, Zhangzhou, Fujian, China.
Frontiers in endocrinology
|June 24, 2025
概括
较低的血清25-氧维生素D (25[OH]D) 水平与2型糖尿病 (T2DM) 中的糖尿病外围神经病变 (DPN) 有关. 测量25[OH]D可能有助于选T2DM患者的DPN风险.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 代谢疾病 代谢疾病
背景情况:
- 糖尿病外围神经病变 (DPN) 是2型糖尿病 (T2DM) 的常见并发症.
- 血清25-氧维生素D (25[OH]D) 缺乏症在T2DM患者中很普遍.
- 25[OH]D水平与DPN之间的关系需要进一步调查.
研究的目的:
- 检查T2DM患者血清25(OH) D水平与DPN之间的关联.
- 评估25(OH) D对DPN发展的预测能力.
主要方法:
- 患有T2DM的参与者根据血清25(OH) D水平被分为三组:缺乏,不足和正常.
- 进行了统计分析,以评估25(OH) D和DPN之间的相关性,同时考虑了其他临床指标.
- 采用多变量分析和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 与没有DPN的患者相比,DPN患者的血清含量显著降低了25(OH) D3和总量25(OH) D.
- 身体质量指数 (BMI),静止心率 (RHR),甘油三 (TG),自由三甲素 (FT3) 和血尿素 (BUN) 也在各组之间有显著差异.
- 多变量分析确定了25 ((OH) D3,总25 ((OH) D,FT3,BMI和RHR作为DPN的独立风险因素. 在ROC分析中显示了25(OH) D3 (18.85 ng/mL) 和总25(OH) D (19.94 ng/mL) 的最佳切割值,用于DPN预测.
结论:
- 在患有DPN的T2DM患者中,血清25(OH) D水平显著降低.
- 血清25(OH) D水平显示出作为T2DM中DPN的预测标记物的潜力.
- 测量血清25(OH) D可以作为一种简单而有效的查工具,用于T2DM中DPN风险.
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