在过敏性鼻炎中新兴的新生物标志物:叙述性审查
Tejaswi Mishra1, Ksbs Krishna Sasanka1, Sree Sudha Ty2
1Otorhinolaryngology-Head and Neck Surgery, All India Institute of Medical Sciences, Deoghar, Deoghar, IND.
新型生物标志物如皮奥斯和microRNA-155显示出对诊断过敏性鼻炎 (AR) 和预测治疗反应的前景. 进一步的研究旨在将这些标记物整合到个性化的AR护理中.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 生物标志物发现发现
背景情况:
- 过敏性鼻炎 (AR) 是一种广泛的IgE介导炎症性疾病,对公共健康有重大影响.
- 目前AR的生物标志物在诊断和治疗反应预测方面缺乏精度,需要新的方法.
研究的目的:
- 在过去的15年中,审查AR病原和管理的新兴分子标记物.
- 综合关于创新的生物标志物的证据,以改善AR诊断和治疗监测.
主要方法:
- 对AR生物标志物的临床前和临床研究进行了全面的文献搜索.
- 对已识别的生物标志物的分析,包括皮奥斯,microRNA-155,HIF-1α,GZMA,CD39,ORM,APOH和SERPINB3.
主要成果:
- 临床前研究揭示了新型标记物在免疫调节和炎症中的作用.
- 临床试验表明,佩里奥斯,miRNA-155,ORM和APOH在预测疾病严重程度和治疗结果 (免疫疗法,葡萄糖皮质类药物) 中具有潜力.
- CD39和细胞因子概况显示出疾病分层的前景.
结论:
- 新兴的生物标志物为增强AR诊断,预后和治疗监测提供了潜力.
- 大多数新型生物标志物需要进一步验证和整合到AR精准医学小组中.
- 未来的研究应该集中在多中心验证和AR生物标志物开发的标准化协议上.
更多相关视频
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
相关概念视频
Allergic Reactions
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
