人工智能和相关技术挑战在MALDI MS和MALDI-MSI的最新应用:一个小审查
1Genomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Mass spectrometry (Tokyo, Japan)
|June 24, 2025
概括
人工智能 (AI) 和机器学习 (ML) 正在推进质谱 (MS) 数据分析,特别是在MALDI-TOF MS和MS成像中. 本综述强调了人工智能应用和必要的样本准备,以获得准确,高通量结果.
科学领域:
- 分析化学 分析化学
- 计算生物学 计算生物学
- 生物技术是生物技术.
背景情况:
- 质谱 (MS) 产生了庞大的数据集,需要先进的分析方法.
- 目前的MS数据分析在识别,量化和解释速度和准确性方面面临挑战.
- 机器学习 (ML) 和人工智能 (AI) 显示出克服这些局限性的前景.
研究的目的:
- 在MALDI-TOF MS和MALDI-MSI数据分析中审查最近的AI应用,重点是监督的ML.
- 讨论采样技术和样本准备在人工智能驱动的MS中的关键作用.
- 突出AI在加速数据采集和提高分析准确性的潜力.
主要方法:
- 利用高通量MS数据来推进ML技术.
- 人工神经网络的应用,以加速数据采集.
- 专注于对 MALDI-TOF MS 和 MALDI-MSI 数据进行监督的 ML 算法.
主要成果:
- 人工智能模型展示了与MALDI和MALDI成像中的采样技术相关的改进准确性.
- 人工神经网络正在克服传统的障碍,加速数据采集.
- 人工智能驱动的化学特异性和空间映射分析正在获得引力.
结论:
- 人工智能,特别是监督的ML,为分析复杂的MS数据提供了强大的工具.
- 优化样本准备和采样技术对于深度学习模型中高质量的数据至关重要.
- 人工智能集成承诺从MS获得更快,更准确的洞察力,特别是在成像应用中.
更多相关视频
09:08Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
Published on: December 22, 2020
6.4K
09:38Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Published on: November 26, 2013
14.3K
相关概念视频
MALDI-TOF Mass Spectrometry
5.3K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
5.3K
Matrix-Assisted Laser Desorption Ionization (MALDI)
462
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI spectrometry is widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...
462
Peptide Identification Using Tandem Mass Spectrometry
6.8K
Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.8K
Tandem Mass Spectrometry
1.3K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
1.3K
Mass Spectrometry: Complex Analysis
905
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
905
