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对微生物组和宿主转录组的综合分析揭示了组织微生物群和早期乳头甲状腺癌瘤进展之间的相关性
Xiuwen Tong1,2, Xipei Chen1, Chen Shen1
1Department of Thyroid and Breast Surgery, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Frontiers in cellular and infection microbiology
|June 24, 2025
概括
乳头甲状腺癌 (PTC) 瘤微环境中存在着不同的微生物群落. 这些微生物与宿主基因和细胞相互作用,可能通过炎症驱动PTC的发展.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 瘤微环境中的微生物越来越多地被认为对癌症的发展和进展起着作用.
- 在乳头甲状腺癌 (PTC) 中,特定的微生物组成及其功能含义在很大程度上仍未被描述.
研究的目的:
- 在PTC中研究组织微生物组和宿主基因表达.
- 在PTC中探索微生物,宿主基因和免疫细胞之间的相互作用.
- 确定潜在的微生物生物标志物和参与PTC瘤发生的分子机制.
主要方法:
- 16S rRNA amplicon测序用于分析微生物群落.
- 用RNA-Seq来描述宿主转录组的特征.
- 进行了关联分析,以将微生物组成与基因表达和免疫细胞概况联系起来.
主要成果:
- 与相邻的非癌性组织相比,PTC组织表现出不同的微生物和功能组成.
- 特定的微生物属 (例如,普拉诺菌,林诺细菌,细菌) 与PTC和临床阶段有关.
- 不同基因表达显示了细胞间通信和细胞外矩阵功能的丰富.
- 观察到免疫细胞组成的显著变化,表明有活跃的免疫反应.
- 确定了关键的微生物基因和微生物细胞相互作用,主要涉及与炎症相关的途径.
结论:
- 该研究描述了PTC组织微生物组及其与宿主基因表达和免疫反应的关联.
- 已识别的微生物基因/细胞相互作用为PTC的分子机制提供了洞察力.
- 这些发现为了解微生物组在PTC瘤发生和进展中的作用提供了潜在的候选生物标志物.
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