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阿斯特拉加卢斯膜的提取物通过整合多组学和PI3K/AKT信号通路来减轻性结肠炎

Jiaying Zhu¹, Chenhuan Shentu¹, Qingling Meng¹

¹School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in pharmacology

|June 24, 2025

概括

阿斯特拉加勒斯膜 (AM) 提取物通过恢复肠道微生物群平衡和减少炎症来缓解性结肠炎 (UC). 这些好处与PI3K/AKT信号通路有关,为UC治疗提供了新的治疗见解.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病 (IBD),严重影响患者的生活质量.
阿斯特拉加卢斯 (Astragalus membranaceus) 是一种传统的中医药,具有抗炎性质.
在UC中研究AM的治疗潜力对于开发新疗法至关重要.

研究的目的:

在小鼠模型中评估AM提取物在改善硫酸 (DSS) 诱导的大肠炎方面的疗效.
阐明AM提取物对大肠炎产生治疗作用的潜在机制.

主要方法:

建立一个DSS诱导的UC小鼠模型.
口服AM提取物和治疗效果的评估.
对肠道微生物组成 (16S rDNA),短链脂肪酸 (SCFA) 和胆汁酸 (BA) 的分析.
网络药理和实验验证的应用,以确定分子途径.

主要成果:

AM提取物显著缓解了UC症状,并恢复了肠道屏障的完整性.
AM提取物重新平衡了肠道微生物群和正常化的SCFA和BA代谢概况.
机理学研究表明,AM提取物激活PI3K/AKT信号通路.

结论:

艾米提取物在性结肠炎中显示出显著的治疗潜力.
亚米提取物调节肠道失调,并通过PI3K/AKT通路促进有益的代谢物.
这些发现为开发基于AM的UC治疗提供了基础.

关键词:

阿斯特拉加勒斯的膜状.在PI3K/Akt信号通路中.代谢产物的代谢产物微生物失生症是微生物失生症.性结肠炎是一种

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