非编码RNA和酒精使用障碍:对当前研究和知识差距的全面审查
Deepa Upreti1, Rosaline P Kumar1, Justin B J Chen1
1Department of Neuroscience and Experimental Therapeutics, Texas A&M School of Medicine, Bryan, Texas.
Alcohol research : current reviews
|June 24, 2025
概括
非编码RNAs (ncRNAs) 越来越多地研究它们在与酒精有关的疾病中的作用. 研究正在出现,但需要更多的研究来了解改善酒精使用障碍的诊断和治疗机制.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 酒精的使用和滥用对疾病负担,死亡率和社会成本做出了重大贡献.
- 了解分子机制对于开发更好的酒精相关疾病诊断和治疗至关重要.
- 非编码RNAs (ncRNAs) 是可以调节细胞和组织环境影响的调节分子,可能在与酒精有关的病理中发挥关键作用.
研究的目的:
- 对将ncRNA与酒精联系起来的研究进行范围审查.
- 确定现有研究的范围,范围和性质.
- 确定有关ncRNA和酒精研究的当前文献中的空白.
主要方法:
- 使用PRISMA-ScR指南进行系统的文献搜索.
- 包括在2023年12月之前发表的所有物种 (人类,动物,细胞研究) 的同行评审文章.
- 在Medline,Embase和Academic Search Ultimate数据库中进行关键字搜索,然后使用Covidence和Excel进行选和数据提取.
主要成果:
- 综述包括338项研究,其中microRNAs (miRNAs) 是研究最多的ncRNA类型,其次是长非编码RNAs (lncRNAs) 和循环RNAs (circRNAs).
- 研究涵盖了各种器官中与酒精有关的病理,但机械学研究有限.
- 发现了重大研究缺陷,特别是关于潜在机制和充分考虑生物性别,年龄和遗传变异.
结论:
- 与酒精相关的病理学的ncRNA研究领域正在芽.
- 进一步的研究对于识别特定的ncRNA,了解它们在不同器官和疾病阶段的作用以及阐明潜在机制至关重要.
- 新兴的ncRNA研究有望促进酒精使用障碍的诊断和治疗.
更多相关视频
相关概念视频
CNS Depressants: Alcohol and Nicotine
370
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
370
Substance Use Disorders Affecting Sleep
225
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
225
Drug Abuse and Addiction: Pharmacological Phenomena
663
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
663
lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Experimental RNAi
6.3K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.3K
RNA Editing
9.2K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.2K


