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基因预测肠道微生物群和宿主代谢物调解饮食因素与急性髓性白血病之间的因果关系
Jiading Qin1,2, Ling Zhang3, Guangcheng Zhang1
1Department of Hematology and Oncology, Shenzhen University General Hospital, International Cancer Center, Hematology Institution, Haoshi Cell Therapy Institute of Shenzhen University, Shenzhen University Medical School Shenzhen University Shenzhen China.
Food science & nutrition
|June 24, 2025
概括
加工肉类的消费增加了急性髓性白血病 (AML) 的风险. 肠道微生物群和宿主代谢调解这种联系,L-histidine降解作为一种亲致癌途径和提供保护的特定代谢物.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 代谢学 代谢学 代谢学
背景情况:
- 饮食因素与急性髓性白血病 (AML) 的病因有关.
- 连接饮食,肠道微生物群和AML的精确机制在很大程度上仍未被探索.
- 了解这些途径对于制定预防策略至关重要.
研究的目的:
- 研究20种饮食因素对AML风险的因果关系.
- 探索肠道微生物群和宿主代谢物在饮食与AML关系中的调解作用.
- 为了确定参与AML发展的特定微生物和代谢途径.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据进行双样本孟德尔随机化 (MR) 分析.
- 两步MR框架评估通过肠道微生物群和宿主代谢物进行调解.
- 使用逆方差加权 (IVW),MR-Egger和MR-PRESSO灵敏度分析进行稳定性检查.
主要成果:
- 加工肉类消费与AML风险增加有显著的因果关系 (OR=15.111,p=0.033).
- 肠道微生物群中的L-histidine降解I途径充当了一种亲致癌媒介 (19.5%的效果).
- 主体代谢物,包括甘油和高密度胆固醇自由胆固醇/总脂质比率,已证明具有保护作用.
结论:
- 加工肉类的消费是AML的风险因素,由肠道微生物群-代谢物轴介导.
- 特定的微生物途径 (L-histidine降解) 促进AML,而某些宿主代谢物提供保护.
- 这些发现突出了通过饮食和代谢调节来预防和干预AML的潜在目标.
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