雌激素度适用于适当的性别确认女性化疗法:系统性审查
Gabrielle N Winston-McPherson1, Tiffany A Thomas2, Matthew D Krasowski3
1Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA.
LGBT health
|June 24, 2025
概括
目前的指导方针建议在跨性别女性的激素治疗中使用100-200 pg/mL的雌激素范围. 这次审查没有发现任何证据表明这种范围可以确保足够的女性化或防止不良事件.
科学领域:
- 内分泌学 在内分泌学.
- 肯定性别的护理.
- 药理学 药理学是指药理学的学科.
背景情况:
- 目前的指导方针建议在接受女性化激素治疗 (HT) 的跨性别女性的血清雌激素度为100-200 pg/mL.
- 该范围旨在确保充分的女性化,并最大限度地降低与HT相关的风险.
研究的目的:
- 系统地审查证据,评估推的100-200 pg/mL雌激素范围与变性女性的女性化充足性,不足性,抑制或毒性有关.
- 评估当前关于性别肯定激素治疗中雌激醇度的指南是否基于证据.
主要方法:
- 使用人口/干预/比较者/结果模型进行了系统性审查.
- 在Embase,MEDLINE和Web of Science数据库中搜索 (1999-2023) 发现了49项研究.
- 结果包括治疗不足,充分性,毒性和激素度的指标.
主要成果:
- 该审查确定了49项符合纳入标准的研究.
- 没有研究表明100-200 pg/mL雌激素范围与最佳女性化结果有关.
- 证据没有表明这种范围有效地减少不良事件.
结论:
- 目前的血清雌激醇指南范围为100-200 pg/mL,没有证据支持表明跨性别女性足够的女性化.
- 需要进一步的研究来确定性别肯定激素治疗的最佳雌激素标.
- 临床实践可能需要重新评估对这种特定雌激素度范围的依赖.
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