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在"无PPD"的头发染料中接触过敏原
Carli D Needle1, Emily C Milam1, Aryeh Korman2
1The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.
Dermatitis : contact, atopic, occupational, drug
|June 24, 2025
概括
许多"无PPD"的染发剂含有未申报的偏二胺 (PPD),这是一个常见的过敏原,会引起过敏性接触性皮肤炎 (ACD). 在使用任何新发染料之前,测试至关重要,无论标签如何.
科学领域:
- 皮肤病学 皮肤病学
- 化品科学 化品科学
- 分析化学 分析化学
背景情况:
- 染发剂是过敏性接触性皮肤炎 (ACD) 的常见原因.
- 偏二胺 (PPD) 和相关的芳胺是主要的染发油过敏原.
- 即使使用"无过敏原"或"天然"染发剂,患者也会患上ACD,这表明未披露的或交叉反应的成分.
研究的目的:
- 调查在美国销售的"无PPD"染发剂是否具有常见的染发剂过敏原.
- 量化特定过敏原的存在,如PPD,m-aminophenol等.
- 为了识别发染料配方中未公开的成分.
主要方法:
- 使用高性能液态染色学与高分辨率质谱学 (HPLC-HRMS) 结合使用最销的"无PPD"染发剂的分析.
- 检测和量化目标染发剂的过敏原和成分.
- 检测到的成分与产品成分清单进行比较.
主要成果:
- 在51种测试的染发产品中,有7种含有未申报化合物.
- 五种产品的PPD测试结果呈阳性,其中四种产品明确标有"无PPD".
- 在一些产品中,PPD含量从微量到超过2%的重量有所不同.
结论:
- "无PPD"染发标签可能会误导,因为可能存在PPD.
- 皮肤科医生应建议患有ACD的患者在使用任何新发染料之前进行过敏警报测试.
- 无论营销声称如何,需要对染发剂成分和潜在的过敏原保持警.
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