运动后脑源性神经营养因子和乳酸的同时增加并没有显示出直接的相关性
S K Ashcroft1, K Basclain1, C Woolnough2
1School of Behavioural and Health Sciences, Australian Catholic University, Strathfield, New South Wales, Australia.
Journal of neuroscience research
|June 24, 2025
概括
这项研究发现,虽然运动后脑衍生神经营养因子 (BDNF) 和乳酸水平增加,但总体而言,它们没有显著的相关性. 然而,在特定的群体中注意到了相关性,包括男性和那些具有Val66Met多态度的人.
科学领域:
- 运动生理学 运动生理学
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 在神经元可塑性中起着至关重要的作用,并受到身体活动的影响.
- 乳酸是厌氧运动的代谢副产物,其度随着运动强度而显著变化.
- 在BDNF基因中的Val66Met多态可能会影响BDNF分泌和对刺激的反应.
研究的目的:
- 为了研究BDNF和乳酸盐度在次最大分级运动测试之前和之后之间的关系.
- 检查Val66Met多态性和性别如何影响运动期间的BDNF-乳酸盐关系.
主要方法:
- 31名成年人接受了次最大分级运动测试.
- 运动前和运动后测量了BDNF和乳酸盐度.
- 进行了Val66Met多态的基因定型.
- 用皮尔森相关系数来分析BDNF和乳酸之间的关系.
主要成果:
- 运动后BDNF和乳酸盐度显著增加 (p < 0.001).
- 总体而言,BDNF和乳酸之间没有发现显著的相关性 (运动前:r = -0.256,p = 0.164;运动后:r = 0.112,p = 0.549;变化:r = 0.019,p = 0.921).
- 在运动前观察到BDNF和乳酸之间的适度反相关性,在Val66Met多态 (r = -0.744,p = 0.009) 个体和男性 (r = -0.695,p = 0.006) 中观察到.
结论:
- 最低级分级运动增加了BDNF和乳酸盐水平.
- 在一般人群中,运动后BDNF和乳酸盐度之间存在直接相关性的证据有限.
- 在运动期间,Val66Met的多态性和性别可能会调节BDNF和乳酸之间的关系.
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