额外耳和部淋巴结:深层淋巴功能的生物标志物以及与乳腺癌相关的淋巴风险的影响
James E Fanning1, Angela Chen1, Sarah Thomson1
1Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Journal of surgical oncology
|June 24, 2025
概括
在40%的健康志愿者中观察到功能性淋巴疏通,从上耳淋巴结到上耳淋巴结. 这种表面到深层的途径可能是乳腺癌相关淋巴风险的生物标志物.
科学领域:
- 淋巴系统成像 淋巴系统成像
- 核医学是一种核医学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 从表面到深层的淋巴重定向对于预防与乳腺癌相关的淋巴 (BCRL) 是至关重要的.
- 膀淋巴结表明深层淋巴排水,而外耳淋巴结则表明表面到深层抵押.
- 此前还没有研究过表皮耳和部淋巴结之间的功能连接的体内成像.
研究的目的:
- 通过淋巴切图学来研究外耳淋巴结和膀淋巴结之间的功能连接.
- 评估健康个体的基线表面到深层淋巴排水通路的基线.
- 探索表耳和部淋巴结排水作为BCRL风险的生物标志物的潜力.
主要方法:
- 健康的女性志愿者在每个上肢接受了99-Tcm硫合体的皮内注射.
- 在注射后2小时进行了SPECT/CT成像,以可视化淋巴结中的标记物吸收.
- 两个核医学医生独立审查了扫描,Chi-square测试分析了外耳和部淋巴结排水之间的相关性.
主要成果:
- 分别在57%和51%的手臂中观察到表耳和部淋巴结的排水.
- 在40%的手臂中发生了上耳和上淋巴结的功能性排水.
- 膀淋巴结排水在带上耳淋巴结排水的手臂中明显更频繁 (71%对26%,p < 0.001).
结论:
- 脊和部淋巴结排水有显著的相关性,这表明40%的健康手臂具有功能性的表面到深层淋巴通路.
- 副耳淋巴结和膀淋巴结都没有排水,这可能是BCRL风险增加的潜在生物标志物.
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