关于肠道微生物群与外围动脉疾病之间的关联的叙述性综述
Joong Min Park1, Ian Beckman1,2, Christopher L Delaney1,2
1Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA, Australia.
Vascular medicine (London, England)
|June 24, 2025
概括
肠道疾病,肠道细菌的不平衡,与动脉样硬化和外周动脉疾病 (PAD) 有关. 准肠道微生物群可能为PAD患者提供新的诊断和治疗策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 动脉样硬化涉及炎症,可能是由肠道疾病驱动的.
- 肠道失生症意味着肠道微生物群的组成,功能和多样性的变化.
- 目前有限的研究将肠道微生物群与外围动脉疾病 (PAD) 联系起来.
研究的目的:
- 审查有关肠道微生物群在动脉样硬化发病中的作用的证据.
- 探索失生症如何影响周围动脉疾病 (PAD) 的治疗方法.
- 突出肠道微生物群作为PAD治疗和诊断目标的潜力.
主要方法:
- 文献综述总结了关于肠道微生物群和PAD的当前证据.
- 分析短链脂肪酸 (SCFA) 的作用和运动效应.
- 讨论针对肠道微生物群的潜在个性化治疗方法.
主要成果:
- 肠道微生物群可能通过直接感染或免疫反应启动动动脉硬化.
- 失生症可以影响PAD医疗和手术治疗的疗效.
- 短链脂肪酸 (SCFA) 和运动干预措施显示了与肠道细菌的潜在联系.
结论:
- 肠道微生物群是一个有希望的治疗标和PAD的诊断工具.
- 像共生菌,后生菌和便微生物移植 (FMT) 这样的个性化治疗需要进一步的研究.
- 未来的研究应该集中在将肠道微生物群分析整合到PAD管理中,并探索生物库数据.
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