在自身免疫性疾病中的周周血管三级淋巴体结构
Jörg J Goronzy1,2,3, Cornelia M Weyand1,2,3,4
1Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Immunological reviews
|June 24, 2025
概括
持续性自身免疫性疾病可能源于免疫细胞在淋巴结外形成结构. 这些三级淋巴体结构 (TLS) 拥有弹性T细胞,驱动慢性炎症并提供新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
- 炎症生物学 炎症生物学
背景情况:
- 自身免疫性疾病仍然无法治愈,其特点是慢性炎症.
- 了解持续的自身免疫记忆和缺乏免疫衰竭的机制至关重要.
- 细胞免疫的分散越来越被认为是慢性自身免疫反应的一个因素.
研究的目的:
- 审查新出现的关于分散的细胞免疫如何促进持续的自身免疫反应的数据.
- 探索组织内存T细胞 (TRM) 和三级淋巴体结构 (TLS) 在自身免疫性慢性病中的作用.
- 突出TLS在自身免疫性疾病中的致病作用,并确定潜在的治疗点.
主要方法:
- 审查当前的科学文献和新出现的数据.
- 分析免疫记忆和自身免疫性疲劳背后的机制.
- 检查三级淋巴体结构 (TLS) 的结构,组成和功能.
主要成果:
- 持久的免疫记忆是由组织内存T细胞 (TRM) 和三级淋巴体结构 (TLS) 支持的.
- TLS,主要器官外的淋巴结合物,在慢性免疫刺激期间形成.
- 在自身免疫性血管炎中,进发性TLS携带TCF1hi CD4+ T干细胞,提供持续的致病效应T细胞并促进疾病的慢性化.
结论:
- 分散免疫反应,特别是TLS,在自身免疫性疾病的持续性和慢性性方面发挥着关键作用.
- 在TLS内部的本地干细胞和CD4+T细胞的产生有助于自身反应性免疫的弹性.
- 准TLS和它们所含的干细胞T细胞,为控制自身免疫性疾病提供了一种新的治疗策略.
相关概念视频
01:18Lymphoid Cells and Tissues
1.6K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.6K
01:15Secondary Lymphoid Organs
4.0K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
4.0K
01:16Primary Lymphoid Organs
7.3K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
7.3K
01:23Detailed Structure and Function of Lymph Nodes
2.5K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
2.5K
01:28Functions of the Lymphatic and Immune System
4.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
4.3K
01:23Cells of the Adaptive Immune Response
4.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
4.8K