毒性挑战和金属有机框架 (MOF) 对生物医学应用的当前进展
Mubbashar Abbas1, Zhiwei Liang2, Min Chen2
1National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, 430070, Hubei, China.
Biological trace element research
|June 24, 2025
概括
金属有机框架 (MOFs) 在医学上表现有前途,但毒性和生物相容性问题阻碍了它们的使用. 本综述探讨了MOF的毒性,挑战和用于更安全的生物医学应用的策略.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 金属有机框架 (MOF) 是多孔晶体聚合物,在药物输送,MRI和生物传感方面具有很高的潜力.
- 尽管MOF具有多功能性,但其应用受毒性和生物相容性问题所限制.
研究的目的:
- 综合审查MOF相关的毒性和生物医学应用中的挑战.
- 检查暴露途径,生物机制,以及影响MOF毒性的物理化学性质.
主要方法:
- 对MOF毒性研究的文献综述.
- 对MOF暴露路径 (口服,吸入,皮肤,静脉) 的分析.
- 评估MOF的物理化学特性 (组成,大小,稳定性) 以及它们对毒性的影响.
主要成果:
- MOF的毒性受暴露途径和物理化学性质的影响.
- 关键的毒性机制包括氧化应激,线粒体功能障碍和自干扰.
- 诸如刺激响应系统和MOF复合材料之类的进步旨在提高生物相容性和疗效.
结论:
- 需要新的策略来克服生物医学领域的MOF毒性挑战.
- 未来的研究必须专注于系统的毒性评估和开发更安全的MOF基复合材料.
- 确保MOF的安全性和有效性对于提高其治疗潜力至关重要.
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