关于"用纵向数据进行临床试验分析的新型非线性模型:使用SAS用于频率主义和贝叶斯方法的教程"的评论
M C Donohue1, P S Insel2, O Langford1
1Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, USA.
Statistics in medicine
|June 24, 2025
概括
临床试验中的非线性纵向模型可能会产生偏差,膨胀I型错误,并可能掩盖治疗危害. 研究人员必须解决这些模型的局限性,以准确估计治疗效果和患者安全.
科学领域:
- 生物统计学 生物统计学
- 临床试验设计 临床试验设计
- 纵向数据分析 纵向数据分析
背景情况:
- 非线性纵向比例效应模型在随机临床试验中用于估计治疗效应.
- 这些模型假定随着时间的推移,治疗效果的比例是恒定的.
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