美国老年女性的乳腺癌发病率趋势,按种族,种族,地理和阶段划分
Erica J Lee Argov1, Michelle L Lui1, Anita G Karr1
1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
JAMA network open
|June 24, 2025
概括
乳腺癌发病率趋势在老年女性 (≥65岁) 中因年龄组,种族,种族和诊断时的阶段而异. 这些发现强调了需要针对特定年龄的查指导方针和对促成因素的研究.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 众所周知,乳腺癌 (BC) 发病率趋势在年轻女性中因种族,种族和地理位置而异.
- 在老年女性 (≥65岁) 中,人们对这些趋势的了解较少,尽管74岁以上女性的查指南不同,但这些女性往往被聚合在一起.
研究的目的:
- 为了分类美国BC在老年女性 (65-74岁,75-84岁和≥85岁) 中的发病率趋势.
- 根据诊断阶段,种族和种族,激素受体亚型和地理位置分析趋势.
主要方法:
- 使用美国癌症统计局公共使用数据库 (2001-2019) 进行基于人口的横截面研究.
- 包括所有50个美国州的65岁以上被诊断患有BC的女性.
- 分析了根据年龄调整的发病率和平均年均百分比变化 (AAPCs),使用结点回归,按年龄,阶段,种族/种族和地理分层.
主要成果:
- 发病率随着年龄的增长而下降 (65-74岁的人为530.4/100,000,≥85岁的人为376.8/100,000).
- 在65-74岁的人群中,发病率增加 (AAPC 0.4%),在75-84岁的人群中保持稳定,在≥85岁的人群中下降 (AAPC -1.1%).
- 在种族/种族群体中观察到AAPC的差异;区域诊断减少,远程诊断增加,非西班牙裔黑人妇女的激素受体和ERBB2-阴性癌症比例最高.
结论:
- 在不同年龄组的老年女性中,BC发病率存在显著的种族,种族和特定阶段的模式.
- 将BC发病率按年龄组进行分类,与查指南保持一致,至关重要.
- 需要进一步的研究来探索查模式对趋势和死亡率的影响.
相关概念视频
01:21Cancer Survival Analysis
458
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
458
01:08Prevalence and Incidence
838
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
838
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
01:25Statistical Methods for Analyzing Epidemiological Data
550
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
550
01:28Current Trends in Nursing I
1.7K
Current trends in nursing include:
1.7K
02:20Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K