相关实验视频

Updated: Sep 18, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

美国神经内分泌瘤瘤的流行病学

Arvind Dasari¹, Katrine Wallace², Daniel M Halperin³

¹Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston.

JAMA network open

|June 24, 2025

概括

神经内分泌瘤 (NENs) 的发病率和患病率正在上升,特别是在早期和分化的类型中. 随着时间的推移,NEN的生存率有了显著的改善,显示出患者结局的积极趋势.

科学领域:

在瘤学瘤学.
流行病学流行病学
癌症研究癌症研究

背景情况:

神经内分泌瘤 (NENs) 是一种异质的恶性瘤群,其发病率不断增加,诊断和治疗范式不断发展.
更新的流行病学数据和美国NEN的生存趋势对于了解疾病负担和改善患者护理至关重要.

研究的目的:

确定美国神经内分泌瘤 (NEN) 的流行病学趋势,包括发病率和流行率.
分析1975年至2021年美国NEN患者的整体生存 (OS) 趋势.

主要方法:

一项采用国家癌症研究所的监测,流行病学和最终结果 (SEER) 计划数据的横截面研究.
分析包括1975年至2021年间诊断的145,447例NEN病例,重点关注年龄调整的发病率,流行率和OS率.
从2000年到2021年,对整体队列和关键子组 (如胃肠道和胰腺NENs) 的生存趋势进行了具体评估.

主要成果:

从1975年到2021年,NEN的年龄调整后发病率增加了5.2倍,局部,差异很好和尾/直肠主要部位的显著增加.
2021年1月1日估计的20年流行率为243,896例;肺部和胃肠道瘤 (GEP) NEN显示了自2000年以来的最高发病率.
从2000-2006年到2014-2021年,NEN的总生存率显著改善 (HR,1.42),平均寿命为11.8年;生存率因年龄,阶段,等级和主要部位而异.

结论:

随着NEN的发病率和患病率的增加,主要归因于早期疾病的诊断增加.
在研究期间观察到NEN的总生存率有显著改善,这表明管理和治疗方面取得了进展.
持续的流行病学监测和对生存数据的分析对于优化NEN患者的护理策略至关重要.

更多相关视频

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

相关概念视频

Prevalence and Incidence

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...