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长期接触补充和替代医学导致神经表皮生长因子类1膜性脏病

Sangeetha Priya¹, S Arivazhagan², Dilip Kumar³

¹Junior Resident, Department of General Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, Corresponding Author.

The Journal of the Association of Physicians of India..

|June 24, 2025

概括

本案例报告强调神经表皮生长因子类1 (NELL-1) 是膜性病,一种病的原因. 患者患者患者

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学

背景情况:

膜性腎病 (Membranous nephropathy,简称MN) 是一种引起成年人性综合征的球膜性疾病.
脂酶A2受体 (PLA2R) 是MN中最常见的抗原;然而,NELL-1是一种新兴的抗原.
本案涉及NELL-1-阳性MN,可能与含的补充和替代药物有关.

研究的目的:

报告一种罕见的NELL-1-阳性膜性病.
调查从补充和替代药物中暴露于的潜在作用在NELL-1-阳性的MN中.

主要方法:

一名50岁的女性出现了性综合征和休克的症状.
诊断工作包括实验室检测,脏活检和抗原面板.
脏活检证实了膜性脏病和急性间歇性炎;抗原组显示了NELL-1阳性.

主要成果:

该患者被诊断为NELL-1-阳性膜性病,对PLA2R和THSD7A负.
来自补充和替代药物的暴露被确定为可能的原因.
用IV脉冲类固醇治疗导致脏参数的逐渐改善.

结论:

NELL-1 是一种罕见的膜性病的一种已识别的抗原.
暴露于可能引发NELL-1-阳性膜性病.
停止使用诱导剂和类固醇治疗解决了这种情况.

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