铁过载对输血依赖性thalassemia患者骨矿物质密度的影响
Sonia Gupta1, Siddharth Bhargava2, Rajesh Kumar3
1Associate Professor, Department of Immunohematology and Transfusion Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
The Journal of the Association of Physicians of India..
|June 24, 2025
概括
输血依赖性沙拉西米亚 (TDT) 患者的低骨矿物质密度 (BMD) 率很高. 血清费里水平升高,表明铁过载,在TDT中与骨质疏松症和骨质疏松症有显著联系.
科学领域:
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨病是输血依赖性沙拉西米亚 (TDT) 的常见并发症.
- 在TDT中,多种因素导致骨代谢受损,包括铁过载和内分泌干扰.
- 血清费里水平是铁过载的标志物.
研究的目的:
- 调查TDT患者血清费里水平和骨矿物质密度 (BMD) 之间的相关性.
- 评估TDT患者低BMD的患病率.
主要方法:
- 对124名TDT患者 (>5岁) 的回顾性观察研究.
- 用双能量X射线吸收计 (DXA) 测量腰椎和大腿部的BMD.
- 血清费里,,,性酸酶和维生素D的水平记录并与骨质疏松相关.
主要成果:
- 低BMD的高患病率:骨质疏松症60%和腿部部骨质疏松症3.2%;骨质疏松症61.2%和腰椎骨质疏松症17.7%.
- 与骨质疏松症患者和骨质疏松症患者的血清费里水平显著高于骨质疏松症患者和正常的骨质疏松症患者的血清费里水平 (p < 0.001).
- 1918 ng/mL的血清费里丁切断值预测了骨质疏松症,敏感度为80.4%,特异性为87.5%.
结论:
- TDT患者表现出低BMD的大量患病率,特别是在腰椎.
- 在TDT中,血清费里水平升高与骨质疏松症和骨质疏松症密切相关.
- 建议进行常规的BMD评估,以便在TDT中早期检测和管理骨并发症.
相关概念视频
01:24Factors Affecting Erythropoiesis
3.7K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.7K
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:22Bone Marrow Sampling and Transplants
507
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
507
01:27Disorders of Erythrocytes
1.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.3K
01:31Essential Minerals for Bone Health
4.5K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.5K
01:28The Early Endosome: Endocytosis of Transferrin
3.5K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.5K