纳塔利祖马布治疗多发性硬化症患者的疲劳:磨损有多大责任?
Giuseppe Magro1, Stefania Barone2, Angelo Pascarella2
1Lamezia Terme Hospital, Neurology Deptartment, Catanzaro, Italy.
Brain research
|June 24, 2025
概括
纳塔利祖马布 (NTZ) 治疗多发性硬化症 (MS) 患者的疲劳通常是磨损症状 (WoS). 这项研究发现,抑郁症不会影响与NTZ相关的疲劳,这表明它.
科学领域:
- 神经学 神经学
- 临床药理学 临床药理学
背景情况:
- 疲劳是一种常见的多发性硬化症 (MS) 症状,也是纳塔利祖马布 (NTZ) 治疗患者的主要磨损症状 (WoS).
- 诸如情绪障碍等因素对NTZ相关疲劳,特别是WoS的影响需要进一步调查.
研究的目的:
- 探索接受NTZ治疗的MS患者疲劳和抑郁之间的相关性.
- 在这个患者队伍中,要区分慢性疲劳和疲劳作为WoS.
主要方法:
- 87名接受NTZ治疗的多发性硬化患者在输注日被评估疲劳类型 (习惯性与WoS).
- 患者被分为慢性疲劳,终端剂量疲劳或没有疲劳的组.
- 临床评价包括EDSS,FSMC,BDI-II,MSQoL-29,STAI-Y和SDMT. 在临床评价中,我们使用了多种方法.
主要成果:
- 84%的患者报告疲劳;34.5%的患者经历了终端剂量疲劳,49.4%的患者患有慢性疲劳.
- 与终端剂量疲劳组相比,慢性疲劳组的BDI-II得分较高 (p < 0.01).
- 在没有疲劳和结束剂量疲劳组之间,没有发现情绪障碍或BDI-II的显著差异.
结论:
- 抑郁症和情绪障碍似乎没有影响NTZ治疗的MS患者经历的最终剂量疲劳.
- 在接受NTZ治疗的MS患者中,疲劳作为WoS可能是不同的,并且与药物的作用机制直接相关.
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