双相情感障碍和疼痛投诉的门诊患者的物质使用障碍
1Service d'Addictologie et de Pathologies duelles, CHU Clermont-Ferrand, Université Clermont-Auvergne, CNRS, Clermont-Auvergne INP, Institut Pascal (UMR6602), 58 rue Montalembert, 63003 Clermont-Ferrand, France.
Journal of affective disorders
|June 24, 2025
概括
在双相情感障碍 (BD) 中,更高的疼痛强度与酒精使用障碍 (AUD) 的病史有关. 抑郁症,焦虑和情绪波动部分解释了这种联系.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 双极性障碍 (BD) 经常与疼痛和物质使用障碍 (SUD) 一起发生.
- 在BD患者中,疼痛强度和SUD之间的关系尚不清楚.
- 了解这些并发症对于有效的治疗策略至关重要.
研究的目的:
- 调查BD患者的疼痛强度和SUD之间的关联.
- 为了确定患有疼痛和SUDs的BD患者的特定特征.
- 探索影响BD中疼痛-SUD关系的临床调解者.
主要方法:
- 利用了FACE-BD队列的数据,包括BD型I或II型患者.
- 使用EQ-5D-5L尺度对疼痛严重程度进行分类.
- 采用双变量分析,多重回归和路径分析来检查关联和调解.
主要成果:
- 近一半的BD参与者 (48.9%) 报告疼痛.
- 在BD患者中,较高的疼痛水平与有史以来的酒精使用障碍 (AUD) 有显著的关联.
- 患有AUD和中度至极度疼痛的个体表现出焦虑和恐慌障碍的风险增加.
- 路径分析表明,抑郁,焦虑和情绪不稳定性部分介导了终身AUD和疼痛之间的联系.
结论:
- 在BD中报告的疼痛强度与终身AUD病史有关.
- 这些发现强调了疼痛,AUD和BD中的其他精神疾病之间的复杂相互作用.
- 需要进一步的研究来阐明这些并发症背后的机制.
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