具有双刃剑的分子在T细胞中发挥作用:对采用T细胞治疗的含义
Marziyeh Samiee1, Saeedeh Salehi1, Leila Mohamed Khosroshahi1
1Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Critical reviews in oncology/hematology
|June 24, 2025
概括
免疫检查点,如PD-1,可以阻碍抗癌免疫力,但也支持T细胞功能. 删除它们可能并不总是有益的,需要在免疫疗法中谨慎调节.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点传统上抑制免疫反应以防止自身免疫.
- 在癌症和慢性感染中,检查点阻碍了抗瘤免疫力.
- 目前的疗法往往针对免疫检查点来促进T细胞反应.
研究的目的:
- 探索免疫检查点分子的复杂和双重作用.
- 突出免疫检查点功能在免疫治疗中的含义.
- 倡导针对免疫检查点采取更细微的方法.
主要方法:
- 审查关于免疫检查点功能新兴研究.
- 对特定检查点的分析,包括PD-1,TIM-2,A2aR,2B4和EP2.
- 讨论T细胞代谢,细胞毒性,增殖和分化.
主要成果:
- 免疫检查点在简单的抑制之外发挥着多方面的作用.
- 检查点的删除可能会对T细胞代谢,细胞毒性和持久性产生负面影响.
- 这些分子对于T细胞分化和记忆形成至关重要.
结论:
- 免疫检查站是免疫调节中的双刃剑.
- 针对检查站的目标需要仔细考虑它们的有益作用.
- 未来的免疫疗法应该考虑到这些分子的复杂功能.
相关概念视频
T Cell Activation and Clonal Selection
5.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
5.8K
Tumor Immunotherapy
675
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
675
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Antigens Involved in Adaptive Immunity
700
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
700
Cell-mediated Immune Responses
74.1K
Overview
74.1K
Cytotoxic T Cells-mediated Immune Response
2.5K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
2.5K


