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耐NIR-II响应的铜多光催化剂用于热和热
Qinglin Wei1, Xuejiao Song1, Xiaorui Wang1
1Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), School of Physical and Mathematical Sciences, Nanjing Tech University (Nanjing Tech), Nanjing 211816, China.
Acta biomaterialia
|June 24, 2025
概括
这项研究引入了一种新型的光催化剂 (Cu-NC@PEG),它使用近红外光来触发cuproptosis和pyroptosis,为抗亡的癌细胞提供了一种有效的策略.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 癌症治疗 癌症治疗
背景情况:
- 癌细胞往往会对亡产生抵抗力,从而限制了传统的治疗方法.
- 质和热是细胞死亡途径,有可能克服质抵抗力.
- 瘤微环境因素和有限的铜度阻碍了cuproptosis和pyroptosis诱导的有效性.
研究的目的:
- 开发一种光激活系统,用于协同诱导杯和热.
- 为了增强对抗抗亡耐药癌细胞的治疗疗效.
- 研究ROS放大和双细胞死亡诱导的机制.
主要方法:
- 开发DSPE-PEG2000修改的铜化碳基光催化剂 (Cu-NC@PEG).
- 使用第二次近红外 (NIR-II) 激光照射进行光激活.
- 调查ROS生成,通过酶介导的GSDMD裂变的热,以及通过酸性TME中的Cu+介导机制的cuproptosis.
- 评估对线粒体损伤,ATP可用性和铜代谢平衡的协同效应.
主要成果:
- 在NIR-II照射下,Cu-NC@PEG有效地产生超氧化和基.
- 实现了热和热的协同诱导,导致癌细胞死亡的增强.
- 酸性瘤微环境和释放的铜离子在放大ROS和激活两种死亡途径方面发挥着至关重要的作用.
- 来自热的线粒体损伤通过破坏铜平衡来增强 cuproptosis.
结论:
- Cu-NC@PEG 作为一种有效的光激活系统,用于放大反应性氧物种 (ROS).
- 通过ROS放大和铜离子释放来诱导热和热的协同作用显示出癌症治疗的前景.
- 这种方法提供了一种潜在的策略,以克服癌细胞中的亡抵抗.
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