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相关概念视频

Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Engineering a microbial platform for the biosynthesis of anthranilic acid and its derivatives.

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相关实验视频

Updated: Sep 18, 2025

Constructing and Visualizing Models using Mime-based Machine-learning Framework
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用机器学习在基因组规模上建模宿主通路动态.

Charlotte Merzbacher1, Oisin Mac Aodha2, Diego A Oyarzún3

  • 1School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK.

Metabolic engineering
|June 24, 2025
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概括
此摘要是机器生成的。

这项研究引入了一种新的计算方法,结合了动力学和基因组规模的代谢模型,用于预测工程微生物中的动态代谢行为. 这种方法加速了用于可持续化学品生产的菌株设计.

关键词:
基因组规模的代谢模型动力学模型 动力学模型机器学习 机器学习

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科学领域:

  • 代谢工程是代谢工程.
  • 合成生物学 合成生物学
  • 计算生物学 计算生物学

背景情况:

  • 路径工程是可持续化学生产的关键.
  • 预测工程宿主中的动态代谢变化是一项挑战.
  • 目前的基因组规模模型缺乏动态模拟能力.

研究的目的:

  • 开发一个新的计算框架,整合动力学和基因组规模的代谢模型.
  • 为了能够预测发酵期间的动态代谢物和酶行为.
  • 改进微生物生产系统的计算菌株设计.

主要方法:

  • 集成的运动路径模型与基因组规模的代谢模型.
  • 采用替代机器学习模型来加快流量平衡分析 (FBA) 计算.
  • 模拟的局部非线性动态由全球宿主代谢状态告知.

主要成果:

  • 实现了超过两个数量级的模拟加速.
  • 证明了对大肠杆菌中代谢物动态的一致预测.
  • 成功预测了遗传干扰和不同碳源的影响.

结论:

  • 综合建模方法为计算应变设计提供了一个全面的框架.
  • 该方法有助于对动态控制电路和优化策略进行选.
  • 这项工作弥合了代谢工程中静态和动态建模之间的差距.