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基于纳米酶的协同疗法:FeCo-NC用于有效的细菌根除和伤口组织再生

Xiaolong Zhu¹, Wei Lu¹, Ziyi Li¹

¹National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, 210023 Nanjing, China.

Journal of colloid and interface science

|June 24, 2025

概括

这项研究引入了一种新型纳米酶 (FeCo-NC),该纳米酶结合光热和化学动力疗法,有效地消除MRSA和大肠杆菌等抗生素耐药细菌,促进伤口愈合.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
抗菌研究抗菌研究

背景情况:

细菌感染对健康构成重大威胁,因抗生素耐药性增加而加剧.
开发新的抗微生物策略对于对抗耐药性病原体至关重要.
传统的抗生素由于广泛的微生物耐药性而面临限制.

研究的目的:

设计和合成一个双单原子纳米酶 (FeCo-NC) 用于协同抗菌疗法.
为了评估FeCo-NC的抗菌疗效和伤口愈合潜力.
调查FeCo-NC抗菌作用的潜在机制.

主要方法:

合成和表征FeCo-NC纳米酶与Fe,Co和Fe-Co单原子位点在添加碳上.
评估催化性能,光热特性和反应性氧物种的产生.
对抗MRSA和大肠杆菌的抗菌活性在体外和体内评估,以及转录组分析.
对促进伤口愈合的分析,包括减少炎症和组织再生.

主要成果:

与单原子对应物相比,FeCo-NC表现出优越的催化性能和光热转换效率.
通过FeCo-NC的协同光热和化学动力学疗法实现了MRSA和大肠杆菌的高细菌消除率 (>99%).
FeCo-NC调节了细菌基因表达,并证明了明显的伤口愈合加速与减少炎症.

结论:

FeCo-NC纳米酶为细菌感染提供了一个有前途的无抗生素治疗策略.
双疗法方法有效地对抗抗生素耐药细菌,增强伤口愈合.
这种纳米酶为治疗受感染的伤口和解决抗菌素耐药性的可行替代品.

关键词:

化学动力学疗法是一种化学动力学疗法.一个FeCo单原子纳米酶的纳米酶.在NIR-II光热照明系统中,光热照明是NIR-II.协同作用的抗菌药物.伤口愈合伤口愈合

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