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人类白细胞抗原及其与口腔潜在恶性疾病的关联 - 一项系统性审查和元分析

Bharathi M Purohit¹, Uma Kanga², Abhinav Singh³

¹Asssociate Professor, Division of Public Health Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Human immunology

|June 24, 2025

概括

某些人类白细胞抗原 (HLA) 基因基因与口腔潜在恶性疾病 (OPMD) 有关. 需要进一步的研究来了解HLA在OPMD发展中的作用及其作为生物标志物的潜力.

科学领域:

免疫遗传学免疫遗传学
口腔瘤学口腔瘤学
系统审查是系统的审查.

背景情况:

人类白细胞抗原 (HLA) 基因对免疫力至关重要,并与自身免疫性疾病有关.
在口腔癌和口腔潜在恶性疾病 (OPMD) 中HLA的作用需要进一步研究.
这一系统性审查综合了OPMD中HLA等位基因的遗传倾向的证据.

研究的目的:

系统地审查和综合当前关于HLA等位基因与OPMD发展风险之间的关联的证据.
探索特定HLA等位基因在OPMD发生中的潜在保护性或易感性作用.
确定当前研究中的差距,并建议未来的方向.

主要方法:

在主要数据库 (Medline,PubMed,Cochrane,Scopus,Web of Science,EMBASE) 进行了全面的文献搜索,直到2024年6月.
在系统审查过程中遵循了PRISMA指南.
9项涉及6493名参与者的研究 (757名OPMD患者,5736名对照) 分析了HLA关联,并使用纽卡斯尔-太华工具评估了偏差风险.

主要成果:

特定的HLA等位基因与不同的口腔病变有联系.
HLA-DR2和HLA-DR6 (包括DRB1*14) 在口腔平菌中更常见.
HLA-B7,HLA-A10和HLA-DR3与口腔下纤维化有关.

结论:

某些HLA基因基因表现出一种倾向于口腔前性疾病的发展.
了解OPMD背后的分子机制至关重要.
未来的大规模,多民族人口研究建议探索HLA作为OPMD诊断和治疗的潜在生物标志物.

关键词:

遗传学是一个遗传学.人类白细胞抗原.口腔平坦类.口腔潜在的恶性疾病.在口腔下粘膜纤维化.

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