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在体内生物机械特征分析上升大动脉动脉瘤使用多维动态CTA

Cheng-Wei Yang¹, Lan Cao², Tianming Huang²

¹Department of Imaging and Interventional Radiology, DeltaHealth Hospital Shanghai, Shanghai, China.

Journal of biomechanics

|June 24, 2025

概括

新的生物力学标志物SSI,dSSI,PERI和Rs显示出对评估上升胸前大动脉动脉瘤 (ATAA) 破裂风险的前景. 与Marfan患者和健康对照患者相比,非Marfan ATAA患者表现出明显的生物力学特征.

科学领域:

心血管成像和生物力学
医疗工程医学工程
大动脉疾病研究研究

背景情况:

上升的胸前动脉动脉瘤 (ATAA) 具有显著的破裂风险.
准确的生物力学评估ATAA对于风险分层至关重要.
目前的方法可能无法完全捕捉上升性大动脉的复杂机械行为.

研究的目的:

使用多维动态计算机断层扫描血管学 (MD-CTA) 分析ATAA的生物力学特征.
评估新的生物力学参数,以评估ATAA墙壁力学和能量储存.
为了区分非马芬ATAA,马芬综合征和健康个体的生物力学特征.

主要方法:

从30名受试者的MD-CTA图像中重建大动脉模型 (20名ATAA患者,10名对照).
应用逆有限元法 (iFEM) 来计算墙壁张力和应变.
计算应变刚性指数 (SSI),动态SSI (dSSI),潜在能量储备指数 (PERI) 和应变阻力 (Rs).

主要成果:

在非Marfan ATAA组中,SSI和dSSI明显高于Marfan和对照组.
与对照组相比,非Marfan ATAA组的PERI和Rs都较高,具有显著意义.
在Marfan和对照组之间没有发现生物力学标记的显著差异.

结论:

来自MD-CTA的新型生物机械标记 (SSI,dSSI,PERI,Rs) 显示了ATAA评估的潜力.
这些标记物可能有助于在各种ATAA患者亚组中区分生物力学特性.
进一步验证可以将这些标记作为患者特异性破裂风险评估的补充工具.

关键词:

上升的胸前大动脉动脉瘤.生物机械分析分析马尔法恩·马尔法恩 (Marfan Marfan) 是一个多维动态计算机断层扫描血管图谱多维动态计算机断层扫描

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