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Updated: Sep 18, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

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针对野生类型的EGFR及其耐药突变体,使用erlotinib-aptamer结合剂

Yan Li1, Jian Song1, Ruixin Ge1

  • 1Center for Cell Structure and Function, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.

European journal of medicinal chemistry
|June 24, 2025
PubMed
概括

一种新型的溶酶体向化明体 (LYTAC) 有效降解表皮生长因子受体 (EGFR) 和其在非小细胞肺癌 (NSCLC) 中的耐药突变. 这种新方法克服了耐药性,显示了改善癌症治疗的前景.

关键词:
亚普特美尔 (Aptamer) 是一种药物.药物耐药性 药物耐药性 药物耐药性皮肤表皮生长因子受体.色素向的奇默体有针对性的蛋白质降解降解.

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