间歇性禁食用于夜班工人减肥:一个三臂,优越性随机临床试验
Maxine P Bonham1, Gloria K W Leung1, Michelle Rogers2
1Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.
EBioMedicine
|June 24, 2025
概括
经过修改的间歇性禁食 (IF) 与用于减肥或改善夜班工人胰岛素耐药性的持续能量限制 (CER) 并没有显著差异. 然而,所有参与者都取得了临床上显著的健康改善.
科学领域:
- 代谢健康 代谢健康
- 时间生物学 时间生物学
- 营养科学 营养科学
背景情况:
- 夜班工作与体重增加和2型糖尿病风险增加有关.
- 间歇性禁食 (IF) 和持续能量限制 (CER) 是体重管理的饮食策略.
- 在夜班工作者中IF的有效性需要进一步调查.
研究的目的:
- 为了比较两个修改的IF策略与夜班工人减肥和胰岛素抵抗的CER.
- 评估IF时间 (假日与班次) 对代谢结果的影响.
- 评估二次心脏代谢标志物和整体健康状况的改善.
主要方法:
- 这是一项为期24周的随机对照试验,涉及超重/肥胖的夜班工人.
- 参与者被分配到CER或两个修改后的IF协议之一 (2天/周2100kJ).
- 共同初级结局包括体重和HOMA-IR;二级结局评估胆固醇,血压和身体组成.
主要成果:
- 在IF组和24周CER之间没有体重或HOMA-IR显著差异.
- 与CER相比,IF:2D组显示总和LDL胆固醇的显著降低.
- 所有组的补充剂都显示了体重,胰岛素抵抗和心脏代谢标记的有利变化.
结论:
- 修改后的IF策略对于夜班工人减肥或胰岛素耐药性并不优于CER.
- 尽管没有显著的群体差异,但在完成干预的参与者中观察到实质性的健康改善.
- 进一步的研究可能会探索夜班工人群体的最佳IF时间和坚持.
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