怀孕期间的孕产妇感染和后代的认知结果:全国性的全兄弟姐妹队列研究
Anders Husby1,2,3,4, Kim D Jakobsen2, Jan Wohlfahrt5,6
1Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.
PLoS medicine
|June 24, 2025
概括
怀孕期间母亲感染似乎不会显著影响后代的认知发育. 通常处方的抗微生物药物对儿童的长期认知结果是安全的.
科学领域:
- 围产期流行病学 围产期流行病学
- 发育神经科学的发展神经科学.
- 公共卫生 公共卫生
背景情况:
- 怀孕期间母亲感染很常见,但它们对后代认知的影响仍在争论中.
- 之前的研究表明,对认知发育有潜在的不良影响.
- 了解这些影响对于产前护理和指导至关重要.
研究的目的:
- 调查怀孕期间母亲感染和后代认知结果之间的联系.
- 评估抗微生物药物处方和因感染住院治疗对学校成绩和智商的影响.
- 通过考虑共同的家庭因素来区分影响.
主要方法:
- 使用了全国范围的丹麦兄弟姐妹队列 (n=274,166),出生于1996-2003.
- 将兄弟姐妹数据与孕妇的抗菌素处方和怀孕期间因感染而入院的情况联系起来.
- 在青春期评估后代的学校成绩 (语言,数学) 和智力测试成绩 (IQ).
主要成果:
- 在考虑了家庭因素后,在母亲有抗菌素处方的儿童中,没有观察到学校成绩或智商的一致差异.
- 在怀孕期间因感染住院的母亲也没有显著影响后代的认知结果,当控制共同的家庭因素.
- 在怀孕期间的不同暴露期中,研究结果保持一致.
结论:
- 这项研究不支持怀孕期间常见的孕产妇感染和不良后代认知结果之间的显著联系.
- 结果表明,在怀孕期间通常处方的抗微生物药物的安全性与长期认知发展有关.
- 进一步的研究可能会探索特定的感染类型和未测量的混因素.
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