探索使用前庭耳植入物电气唤起的化合物作用电位的应用
Stan C J van Boxel1, Bernd L Vermorken1, Benjamin Volpe1
1Department of Otorhinolaryngology and Head and Neck Surgery, Division of Vestibular Disorders, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands; Mental Health and Neuroscience Research Institute (MHeNs), Maastricht Universit; Universiteitssingel 40, 6229 ER, Maastricht, the Netherlands.
Hearing research
|June 24, 2025
概括
电气唤起的复合动能 (eCAP) 可以预测带有前庭耳植入器的患者有电气唤起的前庭耳反射 (eVOR) 的存在. 然而,eCAPs对于手术内电极放置或预测听觉感知是不可靠的.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 前庭耳植入物为前庭功能障碍提供了潜在的治疗方法.
- 客观的结果措施对于评估这些植入物的疗效和优化至关重要.
- 电气唤起的复合作用电位 (eCAP) 在神经假体中用于测量神经反应.
研究的目的:
- 探索eCAP在前庭耳植入物研究中的实用性.
- 为了确定eCAP是否可以预测电气引起的前庭眼反射 (eVOR) 和它的错位.
- 评估eCAP用于听觉感知和耳植入物和前置器植入物之间的交叉刺激.
主要方法:
- 在使用各种电极配置的前庭耳植入器的十名受试者中记录了eCAP.
- 该研究评估了eCAPs对eVOR存在,eVOR错位,听觉感知和从耳刺激引起的前庭激活的预测价值.
主要成果:
- 对于eVOR存在,eCAP显示出高的正预测值 (1.0),但低的负预测值 (0.54).
- 跨运河eCAPs与eVOR错位没有相关性.
- 通过eCAPs进行听觉感知预测是低的 (≤0.5),并且在67%的电极中观察到耳到前庭刺激.
结论:
- 玄关eCAP预测eVOR存在,但由于负预测值低,对于手术内电极定位是不可靠的.
- 耳和前庭电极之间的激发传播发生在临床适应范围内.
- 需要进一步的研究,才能充分理解CAP测量在前庭耳植入物中的潜力.
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