一个使用风险加权监测的"危险模型",用于首次检测慢性衰竭疾病
Krysten L Schuler1, Nicholas A Hollingshead1, Steven Heerkens2
1Cornell Wildlife Health Lab, Public and Ecosystem Health, College of Veterinary Medicine, Animal Health Diagnostic Center, Cornell University,, 240 Farrier Road, Ithaca, NY 14850, USA.
Preventive veterinary medicine
|June 24, 2025
概括
慢性衰竭疾病 (CWD) 的野生动物监测可以通过一种新的危险模型来改进. 该模型确定了疾病引入和传播的高风险区域,增强了野生鹿种群的早期检测.
科学领域:
- 野生动物疾病生态学
- 流行病学监测方法 流行病学监测方法
- 保护生物学 保护生物学
背景情况:
- 新出现的传染病对野生动物群体构成重大威胁.
- 有效监测疾病,如慢性衰竭疾病 (CWD) 在自由放牧的鹿是至关重要的,但往往受到知识差距的阻碍.
- 当前的监测方法可能无法充分考虑疾病引入风险和最佳采样策略.
研究的目的:
- 开发和应用一种新的野生动物疾病监测方法,即"危险模型",以加强对新出现的疾病的早期检测.
- 将景观层面的风险,人类活动和动物种群数据纳入监测设计.
- 提高野生动物群体疾病检测的效率和可靠性,特别是白尾鹿的CWD.
主要方法:
- 征求主题专家的看法,以创建由人类活动引入疾病的风险评估.
- 通过将专家衍生的风险感知与鹿群人口统计数据和监测权重重叠加,开发了一个"危险模型".
- 在纽约 (2013-2014) 和田纳西 (2018-2019) 应用了危险模型,用于白尾鹿的CWD监测.
主要成果:
- 危险模型根据鹿种群密度,高风险的鹿类业务以及靠近CWD感染地区来确定高风险县.
- 在该模型应用的田纳西州,首例CWD病例在四个月内被检测出来.
- 该模型的建议采样强度与疾病引入风险最大的地区保持一致.
结论:
- 危险模型为优化野生动物疾病监测提供了一个灵活和可适应的框架.
- 综合风险因素和专家知识,提高了早期发现CWD等疾病的能力.
- 这种方法增加了及时检测和应对新出现的野生动物疾病的可能性.
相关概念视频
Principles of Disease Surveillance
189
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
189
Hazard Rate
191
The hazard rate, also known as the hazard function or failure rate, is a statistical measure used to describe the instantaneous rate at which an event occurs, given that the event has not yet happened. From a probabilistic perspective, it represents the likelihood that a subject will experience the event in a very small time interval, conditional on surviving up to the beginning of that interval. In terms of frequency, the hazard rate can be viewed as the ratio of the number of events to the...
191
Hazard Ratio
261
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
261
Steps in Outbreak Investigation
215
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
215


