条件淘汰赛小鼠模型表明,Copa表达是发展和成年期生存能力所必需的

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Updated: Sep 18, 2025

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Timra Gilson1, Jacob W Astroski1, Wang Qun2

  • 1Indiana University School of Medicine, Department of Dermatology, 545 Barnhill Drive, Emerson Hall 139, Indianapolis, IN, 46202, United States.

Biochemical and biophysical research communications
|June 24, 2025
PubMed
概括

COPI 协同体蛋白α 子单元 (Copa) 对于细胞存活至关重要,因为它缺失会导致小鼠的胚胎致死性. 条件淘汰模式揭示了它在维持神经元健康和预防自身免疫相关的内质网膜应激方面发挥的关键作用.

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