在阿片类药物渴望中使用横直流刺激进行前额叶皮层调节:假控制双盲研究
Ikhlaq Ahmed1, Mohammed Qutishat2, Rima Ikhlaq3
1Central Institute of Psychiatry, Ranchi, Jharkhand, India; Birmingham and Solihull Mental Health Foundation NHS Trust, UK.
General hospital psychiatry
|June 24, 2025
概括
在一项随机试验中,针对右脊侧前额皮层 (DLPFC) 的跨直流刺激 (tDCS) 显著减少了阿片类药物渴望. 这种非侵入性治疗显示了持续的效果,为阿片类药物使用障碍提供了有希望的辅助疗法.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 吸食阿片类药物成对全球健康构成了重大挑战.
- 创新的治疗策略对于管理阿片类药物依赖至关重要.
- 这项研究探讨了一种新的非侵入性神经调节技术.
研究的目的:
- 评估跨直流刺激 (tDCS) 对减少阿片类药物依赖患者的渴望的疗效.
- 为了研究tDCS针对右背侧前额皮层 (DLPFC) 的影响.
- 为了评估治疗效果的持续时间.
主要方法:
- 进行了一项单中心,双盲,随机,假控制试验.
- 40名阿片类药物依赖的男性住院患者连续五天接受了活性右DLPFC tDCS或假刺激.
- 在多个时间点使用强迫性药物使用量表 (OCDUS) 和成严重程度指数 (ASI) 评估了渴望和心理社会功能.
主要成果:
- 在活跃组和假组之间,基线渴望得分没有显著差异.
- 与假装组相比,活跃的tDCS组在治疗后立即和2周和4周后的随访中显著减少了渴望得分.
- 强迫性药物使用量表 (OCDUS) 的得分显示,在整个随访期间,活跃的tDCS组持续减少.
结论:
- 五次右DLPFC tDCS会话导致阿片类药物渴望的快速,显著和持续减少.
- tDCS显示出作为阿片类药物使用障碍患者有效辅助治疗的前景.
- 这些发现支持使用神经调节作为治疗成的治疗选择.
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