儿童烧伤感染中抗菌素耐药性的危险因素:从回顾性队列研究的见解
Anteneh Amsalu1, Anton Alvaro2, Steven Huang2
1Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia.
概括
抗微生物药物耐药性 (AMR) 在儿科感染烧伤中很普遍,像黄金葡萄球菌 (Staphylococcus aureus) 这样的格拉姆阳性细菌很常见. 早期培养确认对于改善高风险患者治疗结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 儿科烧伤护理 儿科烧伤护理
- 微生物学 微生物学
背景情况:
- 儿科患者感染性烧伤带来了重大的临床挑战.
- 了解微生物的谱和它们的抗菌素耐药性 (AMR) 概况对于有效管理至关重要.
- 识别相关的风险因素可以指导预防和治疗策略.
研究的目的:
- 确定感染烧伤的儿科患者的微生物组和抗菌素耐药性 (AMR) 概况.
- 在这个患者群体中识别AMR的相关风险因素.
主要方法:
- 从2011年1月到2023年12月进行了一项回顾性队列研究.
- 分析了3679名儿科烧伤患者的数据,重点关注那些感染烧伤的人.
- 微生物学数据,包括培养和耐药性模式,与临床信息相关联.
主要成果:
- 在3679名患者中,183人 (5%) 患有感染性烧伤,152人 (87.9%的疑似感染) 患有培养阳性烧伤感染 (BWIs).
- 格拉姆阳性细菌 (63.1%) 在BWI中最常见,特别是金黄色葡萄球菌 (32%). 格拉姆阴性细菌 (32.5%) 包括Pseudomonas aeruginosa (5.7%) 在内.
- 在9.8%的患者中发现了对甲基西林耐药的金黄色葡萄球菌 (MRSA). 观察到对常见抗生素的高耐药率. 头部和部烧伤,PICU入院和先前的病史是AMR感染的独立风险因素.
结论:
- 抗菌素耐药性 (AMR) 是儿科感染烧伤的常见和重大问题.
- 早期培养确认对于指导适当治疗至关重要.
- 识别和管理高风险患者 (例如,那些头部/部烧伤或PICU的患者) 对于改善结果至关重要.
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