基于threosulfan与基于busulfan的制备方案对移植结果的影响
Burcu Aslan Candir1, Nazik Okumus1, Ipek Yonal Hindilerden2
1University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkiye.
概括
硫调节疗法在白血病全源干细胞移植中显示出与布苏尔疗法相似的疗效. 硫具有更好的安全性,较少的静脉封闭性疾病和细胞巨核病毒感染.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 全基血造干细胞移植 (HSCT) 是血液学疾病的关键治愈治疗方法.
- 基于busulfan的调节方案是标准的,但与显著的毒性有关.
- 硫正在作为一种潜在的更安全的替代调节剂进行研究.
研究的目的:
- 为了比较基于三硫和基于布苏尔的调节方案的疗效和安全性,在接受白血病HSCT的成年患者中.
- 评估关键的毒性终点,包括静脉封闭性疾病和感染.
- 评估移植,存活率和复发率.
主要方法:
- 对240名患有急性髓性白血病或急性淋巴细胞白血病的成年患者进行了回顾性分析.
- 患者在2010年至2024年期间在土耳其9个中心接受HSCT.
- 基于busulfan和基于treosulfan的调节方案之间的比较.
主要成果:
- 在这两组中,移植是有效的;中性粒细胞的移植在busulfan (13 vs. 15天) 中更快.
- 静脉封闭性疾病 (10.1%对比0.9%) 和细胞巨核病毒感染 (51.2%对比26.1%) 显著高于busulfan.
- 硫的总体存活期为40个月;对于busulfan,没有达到. 复发率是相似的.
结论:
- 在白血病患者中,基于三硫的调节与基于布苏尔的HSCT疗法一样有效.
- 硫显示出更有利的毒性概况,减少了静脉封闭性疾病和细胞巨乳病毒感染的发生率.
- 硫代表了一个可行的替代HSCT调节剂.
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