产后出血和长期心血管疾病风险:一个全面的系统审查和元分析
Fiqih Faizara Ustadi1, Alma Dhiani Paramita1, Cinta Adinda Roswinabila1
1Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
概括
产后出血 (PPH) 显著增加了女性患心血管疾病和血栓栓塞的长期风险. 早期查和干预对于有严重PPH病史的女性至关重要.
科学领域:
- 心血管健康 心血管健康
- 孕产妇健康 孕产妇健康
- 公共卫生 公共卫生
背景情况:
- 产后出血 (PPH) 是导致母亲发病和死亡的主要原因.
- PPH可能对心血管健康产生持久影响.
- PPH与随后的心血管疾病 (CVD) 风险之间的关联需要进一步调查.
研究的目的:
- 系统地审查和元分析PPH与女性心血管疾病风险之间的关联.
- 评估PPH后发生血栓塞栓事件的风险.
主要方法:
- 在主要数据库中进行了全面的文献搜索.
- 包括评估有PPH病史的女性心血管结局的队列研究.
- 来自970多万参与者的数据使用随机效应模型进行了聚合,并进行了子组和灵敏度分析.
主要成果:
- 患有PPH史的女性患心血管疾病的风险增加了1.76倍,血栓栓塞的风险增加了2.10倍.
- 对于那些需要输血的人来说,风险更高,并且持续到分娩后15年.
- 心血管风险在分娩后的第一年是最常见的,特别是在那些有妊娠高血压疾病的人群中.
结论:
- PPH与心血管和血栓栓塞瘤疾病的长期风险显著增加有关.
- 产后心血管风险查和预防性干预对于有严重PPH病史的妇女至关重要.
- 未来的研究应该使用标准化的方法,特别是在低收入和中等收入国家.
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