在巴雷特食道患者内镜活检技术:一个多样设计的研究
Ilse N Beaufort1,2, Sjoerd G Elias3, Elisabeth M P Akkerman1
1Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands.
Endoscopy
|June 24, 2025
概括
对于巴雷特食道监测,单次活检方法与转向吸收技术相结合,显著增加了活检大小,改善了他的病理质量. 这种优化的方法提高了巴雷特食道患者的诊断准确度.
科学领域:
- 胃肠病学 胃肠病学
- 内镜手术是一种内镜手术.
- 组织病理学 组织病理学
背景情况:
- 对巴雷特食道 (BE) 监测的最佳随机活检技术尚不清楚.
- 组织病理学质量对于准确的BE诊断和管理至关重要.
- 不同的活检方法和技术可能会影响样本大小和质量.
研究的目的:
- 为了比较单活检与双活检方法对BE监测中的组织病理学质量的影响.
- 为了评估前进和接近与转向和吸收活检技术的有效性.
- 确定最佳的活检策略,以最大限度地提高BE监测中的活检大小.
主要方法:
- 一个多中心的,因数设计试验 (第I部分) 随机将BE患者分为单或双活检方法和前进和关闭或转向和吸收技术.
- 一项前后研究 (第二部分) 在临床实践中实施了最佳的活检方法和技术.
- 两部分的主要终点是活检大小.
主要成果:
- 在第I部分中,单方法活检比双方法活检大25% (3.34mm2比2.68mm2;P<0.001).
- 转向和吸收技术与前进和关闭 (P = 0.44) 相比,活检大小没有显著差异.
- 在第二部分中,实施单次活检方法和转向吸技术使平均活检大小增加了18% (P = 0.03).
结论:
- 单活检方法优于双活检方法,用于增加BE监测中的活检大小.
- 转向和吸收技术,当与单次活检方法相结合时,最大限度地提高了活检大小.
- 建议采用单次活检方法和转向吸收技术,以提高BE监测中的基因病理质量.
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