在两个大型当代英国队列中,糖尿病足病的发展风险因素
Safoora Gharibzadeh1, Jiyoung Lee2, Patrick Highton3,4
1Leicester Real World Evidence Unit, Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
Diabetes, obesity & metabolism
|June 24, 2025
概括
糖尿病足病 (DFUD) 影响许多人,年龄较大,男性性别,吸烟,白人种族,高血压和HbA1c作为关键风险因素. 这些发现有助于预防糖尿病患者的DFUD.
科学领域:
- 糖尿病的护理和管理
- 慢性疾病的流行病学.
- 糖尿病的血管并发症糖尿病的血管并发症
背景情况:
- 糖尿病足病 (DFUD) 是糖尿病的严重并发症,显著影响生存率.
- 现有的DFUD风险因素数据通常来自小型,有限的研究.
- 需要来自大型队列的强有力的证据来确定DFUD风险因素.
研究的目的:
- 为了确定DFUD在两大,当代英国糖尿病人群中的发病率.
- 确定与DFUD发展相关的社会人口统计学和临床风险因素.
- 为有针对性的DFUD预防战略提供证据.
主要方法:
- 分析了两个独立的大型英国队列:英格兰 (CPRD) 和苏格兰 (SDRN-NDS).
- 在英语队列中包括超过131,000个人,在苏格兰队列中超过260,000人.
- 利用初级,二级和足部诊所数据来确定病例,在队列之间使用不同的方法.
主要成果:
- 在英格兰,DFUD的发病率为每1000人年9.0,在苏格兰为每1000人年4.4.
- 多变量分析显示,年龄较大,男性性别,吸烟,白人种族,较高的缩血压和升高的HbA1c是DFUD的重要危险因素.
- 尽管数据确定方法不同,但在两个队列中都确定了一致的风险因素.
结论:
- 老年,男性性别,吸烟,白人种族,高血压和血糖控制不佳是DFUD的关键预测因素.
- 这些发现为识别患有糖尿病的高风险个体建立了强有力的证据基础.
- 基于这些已识别的风险因素,可以制定有针对性的预防性干预措施.
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