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Updated: Sep 18, 2025

Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study
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Author Spotlight: Decoding RNA Methylation's Role in Pancreatic Cancer - A Single-Base Resolution Study

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通过基因组工程和长读测序方法探索乳腺癌细胞中mRNAs的m5C表写体

Konstantina Athanasopoulou1, Panagiotis G Adamopoulos2, Panagiotis Tsiakanikas1

  • 1Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15701, Greece.

Functional & integrative genomics
|June 24, 2025
PubMed
概括

这项研究揭示了乳腺癌亚型中明显的5-甲基细胞素 (m5C) 甲基化模式,确定了普遍的m5C签名. 证实NSUN2是关键的m5C编写器,影响基因表达和mRNA稳定性.

关键词:
5甲基细胞氨酸5甲基细胞氨酸乳腺癌是什么? 乳腺癌是什么史诗转录组学 史诗转录组学基因表达 基因表达 基因表达纳米孔测序的测序转录后的监管 转录后的监管RNA生物学的RNA生物学在mRNA中发生的修改.

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Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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