艾滋病毒患者的光学连贯性断层扫描血管学测量:系统性审查和元分析
Mohammad Reza Abdol Homayuni1,2, Sepideh Poshtdar1,2,3, Reza Sadeghi1,2
1Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
概括
人类免疫缺陷病毒 (HIV) 患者在斑点的表面和深层毛细血管中显示出较低的血管密度,由光学连贯断层扫描血管学 (OCTA) 检测到. 这些发现突显了艾滋病毒的微血管变化,但对生物标志物的实用性需要进一步验证.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 人类免疫缺陷病毒 (HIV) 可以影响各种器官系统,包括视网膜.
- 视网膜中的微血管变化在艾滋病毒患者中越来越多地被识别出来.
- 光学连贯断层扫描血管学 (OCTA) 提供了一种非侵入性方法来评估视网膜血管结构.
研究的目的:
- 使用OCTA参数系统地评估艾滋病毒患者的斑点和周围斑点血流,血管和 perfusion 密度变化的证据.
- 评估OCTA在识别与艾滋病毒相关的视网膜微血管变化的有用性.
主要方法:
- 对多个数据库 (PubMed,Scopus,WOS,Embase) 的系统审查,以研究艾滋病毒患者的OCTA参数.
- 包含的研究的质量评估.
- 结果的元分析包括表面和深层毛细管 (SCP和DCP),状血管区 (FAZ) 区域和视网膜神经纤维层 (RNFL) 厚度中的血管密度 (VD).
主要成果:
- 分析包括六项研究,包括270名艾滋病毒患者和275名静脉疾病控制组,以及216名艾滋病毒患者和214名RNFL控制组.
- 与对照组相比,在艾滋病毒患者中观察到明显较低的形SCP和DCP血管密度.
- 在艾滋病毒患者中,也注意到时间和鼻的SCP和DCP血管密度下降;在RNFL厚度或FAZ区域中没有发现显著差异.
结论:
- 艾滋病毒患者在表面和深层毛细管中表现出叶和叶血管密度的显著减少.
- 这些OCTA衍生的变化表明与HIV相关的视网膜微血管病变.
- 需要进一步验证,以确定这些OCTA发现在艾滋病毒管理中的诊断生物标志物潜力.
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