对COVID-19和疫苗接种后心脏病发作的肠道微生物不平衡的生物化学洞察力
Mohamed Gamil Mehanna1, Turky Omar Asar2, Habib Changal Mudasir1
1Department of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
World journal of microbiology & biotechnology
|June 24, 2025
概括
以肠道细菌失衡为特征的肠道失调与心肌梗塞 (MI) 有关. 这项研究在心脏病发作患者中发现了特定的细菌转移,表明了潜在的生物标志物和心脏健康的治疗点.
科学领域:
- 微生物学 微生物学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道失调症 (GD) 越来越多地被认为对心血管疾病,特别是心肌梗塞 (MI) 的作用.
- 由肠道微生物转移驱动的炎症是将GD与MI联系起来的关键机制.
- 识别与心脏病相关的特定细菌种群可以导致新的诊断和治疗策略.
研究的目的:
- 研究COVID-19后心肌梗塞 (MI) 患者与健康对照人群之间的肠道微生物组成差异.
- 为了确定潜在的MI风险分层和治疗干预的微生物生物标志物.
- 探索特定细菌种群在促进炎症和损害肠道屏障完整性的作用.
主要方法:
- 使用16S rRNA测序分析了来自30名心脏病患者和20名健康对照者的便样本.
- 主要成分分析 (PCA) 和部分最小平方差异分析 (PLS-DA) 用于区分微生物特征.
- 对细菌操作分类单元 (OTU) 和类型进行了定量分析,以评估微生物失衡.
主要成果:
- 肌痛性心脏病患者的Prevotella细胞减少,Escherichia,Salmonella和Bacteroides细胞增加,这表明肠道的微生物群具有炎症性作用.
- 在心脏病发作患者中观察到有益的Actinobacteria,Bifidobacterium和Lactobacillus的减少,可能会损害肠道屏障功能.
- 发现了性别特异性变化,女性表现出更高的Fusobacterium和Streptococcus,男性表现出更高的Desulfovibrio和Akkermansia.
结论:
- 肠道失生症在MI病理生理学中发挥着关键作用,具有高的促炎细菌和降低有益的SCFA产生类型,加剧炎症.
- 性别特定的微生物变化作为临床生物标志物对心脏病发作风险分层的潜在实用性.
- 基于微生物群的向治疗有望改善心脏病患者的心脏病治疗结果.
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