在甲状腺风暴期间在全身麻醉下进行的全甲状腺切除术,有毒的体外膜氧化:一个病例报告
Hyung Gon Lee1,2, Joon-Suk Bom3, Leyeoin Lee3
1Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Chonnam National University Hospital, 160 Baekseo-Ro, Dong-Gu, Gwangju, 61469, Korea.
Journal of cardiothoracic surgery
|June 24, 2025
概括
本案例研究表明,甲状腺风暴患者在毒性体外膜氧化 (ECMO) 支持下成功进行了紧急甲状腺切除术,该过程因肺血栓塞栓症而复杂. 这突显了在具有先进生命支持的关键内分泌紧急情况中进行手术干预的可行性.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 心胸外科手术 心胸外科手术
背景情况:
- 甲状腺风暴 (TS) 是一种危及生命的内分泌紧急情况.
- 严重的TS会导致血液动力学不稳定,需要体外膜氧化 (ECMO).
- 由于高风险,在不稳定的TS患者中,手术通常是禁忌的.
研究的目的:
- 报告第一个在毒性 (V-V) ECMO上进行的全甲状腺切除术的病例,该病例是由于肺血栓栓塞 (PTE) 复杂的TS.
- 为了证明在复杂的TS病例中手术干预的可行性和安全性,使用先进的血液动力学支持.
主要方法:
- 一名44岁的TS和心脏性休克的男性最初得到了静脉动脉 (V-A) ECMO的支持.
- 随着改善,患者因PTE发展了耐火性低氧症,并转移到V-V ECMO.
- 在V-V ECMO支持下,在全身麻醉下进行了紧急甲状腺切除术.
主要成果:
- 患者的心脏功能在V-A ECMO上有所改善,但持续性心动减速和随后的PTE导致缺氧.
- V-V ECMO提供了必要的呼吸支持,使得关键的甲状腺切除术.
- 患者在手术后成功断了V-V ECMO,并随着心脏功能改善而出院.
结论:
- 完全甲状腺切除术可以安全地在V-V ECMO上进行,在TS患者中具有PTE,给予适当的麻醉管理.
- 这一案例强调了选择正确的ECMO模式对于最佳患者结果的重要性.
- 先进的生命支持,包括ECMO,可以在复杂的内分泌紧急情况下促进必要的外科干预.
相关概念视频
The Thyroid Gland
7.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.0K
Hyperthyroidism I: Introduction
59
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
59
Hyperthyroidism II: Pathophysiology
36
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
36
Graves' Disease I: Introduction
49
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
49
Graves Disease II: Pathophysiology
33
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
33
Hypothyroidism II: Pathophysiology
35
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
35


