相关实验视频
Updated: Sep 18, 2025

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.6K
黄金葡萄球菌促进皮肤病变在患有表皮质溶解牛皮质的患者
Qin Zeng1, Shucui Wang1, Nadira Nurxat2
1Department of Dermatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Experimental dermatology
|June 25, 2025
概括
在中国的Epidermolysis Bullosa (EB) 患者的皮肤微生物组显示出改变的细菌多样性,毒性黄金葡萄球菌菌株的显著增加. 这种失生症与EB严重程度相关,突显了微生物组平衡对患者护理的重要性.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 遗传学 是一个遗传学.
背景情况:
- 牛皮表皮溶解 (EB) 是一种罕见的遗传性疾病,导致极端脆弱的皮肤和伤口.
- 皮肤微生物组在EB病原发生中的作用,特别是在中国人群中,尚不清楚.
- 脑脊髓炎患者出现炎症,由高C反应性蛋白 (CRP) 和血清粉样蛋白 (SAA) 水平表明.
研究的目的:
- 为了研究皮肤微生物组的组成,在中国的个体与Epidermolysis Bullosa.
- 分析EB患者中黄金葡萄球菌的流行率和特征.
- 探索微生物组变化与EB疾病严重程度之间的关系.
主要方法:
- 从29名EB患者 (各种亚型) 采集了120个拭子,包括病变部位,非病变部位和鼻孔.
- 利用16S rRNA amplicon测序和细菌培养进行微生物分析.
- 用动物模型描述黄金葡萄球菌的流行病学和毒性.
主要成果:
- EB患者表现出皮肤菌症,其中占主导地位的是金黄色葡萄球菌,特别是序列类型 (ST) 7.
- 金黄色葡萄球菌 (Staphylococcus aureus) 丰富度与EB严重程度和疾病活性正相关.
- 来自损伤皮肤的金黄色葡萄球菌显示出增强的毒性,与增强的辅助基因调节器 (Agr) 活动有关.
结论:
- 中国的EB患者呈现出改变的细菌多样性和高度毒性黄金葡萄球菌菌株的增加携带.
- 微生物组的改变可能会影响EB疾病的严重程度.
- 保持微生物组平衡对于优化EB患者护理至关重要.
相关概念视频
Skin Diseases and Disorders
4.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.3K
Clinical Applications of Epidermal Stem Cells
2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K
Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Skin Cancer
4.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.6K
Accessory Structures of the Skin: Sebaceous Glands
2.4K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.4K
Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K

