母亲遗传培养在注意力缺陷多动性障碍风险架构中的重要作用
Behrang Mahjani1, Adrianna P Kępińska1, Shelby Smout1
1Seaver Autism Center for Research and Treatment (Mahjani, Kępińska, Smout, Cohen, Caballero, Buxbaum, Grice), Department of Psychiatry (Mahjani, Kępińska, Smout, Cohen, Caballero, Buxbaum, Grice), Department of Genetics and Genomic Sciences (Mahjani, Kępińska, Buxbaum), Department of Artificial Intelligence and Human Health (Mahjani), Mindich Child Health and Development Institute (Mahjani, Buxbaum, Grice), Friedman Brain Institute (Buxbaum), Department of Neuroscience (Buxbaum), and Division of Tics, OCD, and Related Disorders (Grice), Icahn School of Medicine at Mount Sinai, New York; Department of Molecular Medicine and Surgery and Department of Medical Epidemiology and Biostatistics (Mahjani), Karolinska Institutet, Stockholm.
母亲的遗传培养显著影响后代的注意力缺陷多动症障碍 (ADHD) 风险,超出了直接的遗传遗传. 这凸显了母亲环境对ADHD发展的影响的重要性.
科学领域:
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
- 流行病学 流行病学
背景情况:
- 父母因素与后代注意力缺陷多动症 (ADHD) 风险增加有关.
- 具体的途径,包括遗传和环境影响,尚未完全理解.
研究的目的:
- 调查母亲表型对后代ADHD风险的影响.
- 为了区分母性遗传培养效应与直接遗传.
主要方法:
- 使用了瑞典医疗出生登记册 (982,544人) 的数据.
- 将ADHD的责任分为直接添加基因,母体遗传培养和母体共同环境影响.
主要成果:
- 确定了66707名 (7%) 患有多动症的人.
- 母亲遗传培养占ADHD风险的14.3%.
- 母亲半兄弟姐妹的ADHD风险比父亲半兄弟姐妹更高.
结论:
- 母亲基因型通过环境途径影响后代的ADHD风险,超出了直接的遗传传播.
- 建议对父亲的影响进行进一步的研究,以全面了解ADHD风险.
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