在国家患者登记册中,与肌肉炎表型相关的诊断前的感染
Takuma Ohnishi1, Jesse Wilkerson2, Nastaran Bayat3
1Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA.
Clinical and experimental rheumatology
|June 25, 2025
概括
以前的感染,特别是呼吸道和胃肠道感染,可能会影响异常性炎症性肌肉病 (IIM) 亚型. 肺炎与肺部疾病的IIM密切相关,这表明感染有助于IIM表型.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 异常性炎症性肌肉病变 (IIM) 包含多种自身免疫性肌肉疾病,具有不同的临床表现.
- 在塑造IIM临床亚组和表型方面,先前感染的作用仍然不完全理解.
研究的目的:
- 调查IIM诊断前感染与IIM内的特定临床亚组和表型之间的关联.
- 探索感染与肺部疾病之间的潜在联系或在IIM患者中重叠的特征.
主要方法:
- 分析国家肌肉炎患者登记册,包括皮肤肌肉炎 (DM),多肌肉炎 (PM) 和包容体肌肉炎 (IBM) 的成年患者.
- 检查了在IIM诊断前12个月内自我报告的感染和抗生素使用情况.
- 计算了调整的几率比率 (OR) 和95%置信区间 (CI),并对表现为肺部疾病 (LD+) 和重叠肌肉炎 (OM) 的患者进行了具体分析.
主要成果:
- 与IBM相比,DM和PM中感染的频率更高.
- 发烧性疾病和胃肠炎显示,DM和PM的患病率高于IBM.
- 患有LD+和OM表型的患者报告感染的几率增加,肺炎是最强烈相关的感染.
结论:
- 以前的感染,特别是呼吸道和胃肠道感染,可能会导致成年IIM表型的发展.
- 肺炎与肺部疾病特征的IIM表型有显著的关联.
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